From Paul Dano to John Turturro, Amazon’s Mr. and Mrs. Smith features a truly eclectic guest cast.

Though its based on a 2005 movie of the same name, Prime VideosMr.

and Mrs. Smithis something thats increasingly rare these days: an honest-to-goodness TV show.

Maya Erskine and Donald Glover in Mr. and Mrs. Smith

The Donald Glover and Francesca Sloane-created spy thriller understands the required rhythms of its medium very well.

The commitment to the usual TV format also means thatMr.

and Mrs. Smithgets to introduce one hell of a roster of guest stars.

Donald Glover

What follows is a list of theMr.

and Mrs. Smithcast, beginning with our titular Smiths and then continuing on with guest stars in episode order.

Donald Glover as John Smith

In addition to serving as the co-creator ofMr.

Maya Erskine

You probably know Glover from … well, virtually everything.

Hes an intensely busy writer and performer.

He also has an award-winning career as a musician under the name Childish Gambino.

New York, NY - 1/31/24 - Eiza Goznalez attends the Prime Video’s “Mr. & Mrs. Smith” Red Carpet Premiere in New York  -PICTURED: Eiza Goznalez -PHOTO by: Marion Curtis / StarPix for Prime Video -Location: The Weylin Brooklyn

She also voiced the lead character in recent Netflix animated seriesBlue Eye Samurai.

Alexander got his first big break as the brooding vampire Eric Northman inTrue Blood.

Hes also continued to work on television in projects likeBig Little LiesandSuccession.

John Turturro

Previously he appeared as a debauched version of himself in season 3 of GloversAtlanta.

Shes also lined up for a major role in Netflixs upcoming3 Body Problem.

In short: hes a Paul Dano character.

New York, NY - 1/31/24 - Billy Campbell attends the Prime Video’s “Mr. & Mrs. Smith” Red Carpet Premiere in New York  -PICTURED: Billy Campbell -PHOTO by: Marion Curtis / StarPix for Prime Video -Location: The Weylin Brooklyn

Thats what makes him the perfect choice to play enigmatic billionaire Eric Shane.

Turturro is liable to pop up in just about any movie youre watching.

Sharon Horgan as Gavol Martin

Introduced in episode 3 is powerful married couple Gavol and Parker Martin.

Wagner Moura

Playing the better (and richer) half of this duo is Sharon Horgan.

Horgan is an Irish actress, writer, and comedian best known for her expansive work in television.

Billy Campbell as Parker Martin

Playing Parker Martin is Billy Campbell, an immensely recognizable actor.

Parker Posey

Playing the male half of this duo is Wagner Moura, a Brazilian actor and filmmaker.

Moura is undoubtedly best known to American TV audiences for portraying real life drug kingpin Pablo Escobar on NetflixsNarcos.

Next up he can be seen in Alex Garlands filmCivil War.

Ron Perlman

Most recently she played Smith in NetflixsLost in Spacereboot while also turning up in Ari AstersBeau is Afraid.

Ron Perlman as Toby Hellinger

The kid at the center of episode 5 Do You Want Kids?

is actually Toby Hellinger, played by the very much grown up Ron Perlman.

New York, NY - 1/31/24 - Michaela Coel attends the Prime Video’s “Mr. & Mrs. Smith” Red Carpet Premiere in New York  -PICTURED: Michaela Coel -PHOTO by: Marion Curtis / StarPix for Prime Video -Location: The Weylin Brooklyn

This includes his roles inSons of Anarchy,Pacific Rim, andPoker Face.

And for what its worth, thewhole tough guy thing might not be an act.

Sarah Paulson as Therapist

Joining Hot Neighbor and the Smiths themselves asMr.

and Mrs. Smithcharacters without names, Sarah Paulson plays the therapist in episode 6.

All eight episodes of Mr. and Mrs. Smith are available to stream on Prime Video now.